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KMID : 0379520000160040255
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한국독성학회지
2000 Volume.16 No. 4 p.255 ~ p.261
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The Effect of Sodium Arsenite (NaAsO_2) on the Proliferation and Differentiation of Bone Marrow Cell Stimulated by G-CSF to Neutrophilic Granulocyte Lineage Cells
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Han Seong-Su
Park Jae-Hyun
Chung Hye-Joo
Kim Young-Ok
Chung Seung-Tae
Kim Jin-Ho
Choi Kyoung-Baek
Kang Sun-Kyung
Cho Dae-Hyun
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Abstract
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To investigate what kinds effect arsenic exert on the proliferation and differentiation of bone marrow cells to the neutrophilic granulocytes lineage cells, we treated sodium arsenite to murine bone marrow cells without or with the stimulation of G-CSF. When we added the various concentrations oj sodium arsenite to bone marrow cells without the stimulation of G-CSF for I, 3, 5 or 7 days, sodium arsenite did not make an any effect up to 2.5 mutextrm{M}mutextrm{M}mutextrm{M}mutextrm{M}mutextrm{M}mell of G-CSF was induced by the co treatment of 12.5 mutextrm{M}
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KEYWORD
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Sodium arsenite (NaAsO_2), G-CSF, Bone marrow cell culture, Proliferation, Apoptosis
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